The zebrafish which are in good condition are selected and a chemical mutagen is used to induce random point mutation and genotype screens are performed in the progeny to identify the progeny fish carrying a point mutation in gene associated with the desired disease and then the phenotype screens are performed to further identify the model organism that meets human end points regarding the diseases.
We customize three different model to express a stable phenotype includes single gene mutation model, multi gene mutation model and infection model. Target identification model is identifying a particular gene overexpress, suppress or delete to get desired model.
We model zebrafish through metabolic model, diet induced model, cardiovascular models, knockdown model, tumor model, xenograft model, PDX model, infectious model, infectious agent induced model and custom models. Our results provide comprehensive curricula with clear objectives and outcomes tailored to meet an organization’s particular research needs.