Cannabidiol And Zebrafish

Research study on the exposure of CBD in zebrafish states an increase in lifespan but with a significant reduction in fecundity. There are lots of behavioral and immunological research has been undergone on cannabidiol effects in zebrafish.

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What is Cannabidiol Plant?

CBD is a molecule found in the Cannabis sativa plant, generally known as hemp or cannabis. The Cannabis sativa plant contains over 80 known chemical compounds known as cannabinoids. The most well-known component of cannabis is delta-9-tetrahydrocannabinol (THC). CBD is derived from hemp, a type of Cannabis sativa plant that has just trace quantities of THC. Cannabidiol appears to have impacts on certain brain chemicals, although they are not the same as THC’s.

How they are used in Medical Industry?

Parameters Analyzed Cannabidiol in Zebrafish:

There are lots of behavior and immunological research has been undergone on cannabidiol effects in zebrafish ,for example with the help of behavioral studies like open field test, locomotion, startle, stereo, dive test and gene expression analysis like RT-QPCR, immunohistochemical analysis like western blot, neutrophil staining, TUNEL staining has proved study’s like developmental effects of CBD and THC, effects of CBD on caudal fin regeneration in zebrafish as successive modeling. Research study on exposure of CBD in zebrafish also states an increase in lifespan but with a significant reduction in fecundity.

Cannabidiol And COVID 19:

Recent study has stated that Cannabidiol inhibits SARS-CoV-2 replication in human cells and mice. Except for CBD, none of the closely related CBD congeners-like tetrahydrocannabinol (THC), cannabidivar in (CBDV), cannabidiolic acid (CBDA), cannabichromene (CBC), or cannabigerol inhibited SARS-CoV-2 infection. A metabolite of CBD- 7-hydroxy-cannabidiol (7-OH-CBD) effectively inhibited SARS-CoV-2 replication in A549 angiotensin-converting enzyme 2 (ACE2) cells at a non-toxic level. CBD also inhibited SARS-CoV-2 replication by the activation of host IRE1α, RNase ER stress response, and interferon pathways. But these studies only suggest the role of CBD as a potential agent for combating SARS-CoV-2 infection during the early stages.

Conclusion

Cannabidiol host stress and antiviral inflammatory responses study on zebrafish will be an effective model, because of high fecundity and less cost, immediate result availability will not only give fast information but also will help researchers in conducting more experiments in less amount of time and readily available biochemical and genetic information and its genetic similarity to humans supports this statement .so modeling zebrafish proves as an effective tool in discovering vaccines not only for COVID 19 and its complications but also for various other neurological disease to.

Zebrafish Studies:

Toxicology study in adult zebrafish
Modeling in zebrafish study
Toxicology study in larvae
Infection model in zebrafish
zebrafish fertility study
zebrafish neurology model