One of the central questions in biological psychiatry is how genes, molecular pathways, and patterns of connectivity in the brain produce and modulate anxiety behavior. Through the use of numerous behavioral paradigms, genetic/pharmacological screens, and neuroimaging, animals have been extensively used to model anxiety pathogenesis. The zebrafish (Danio rerio) has emerged as a useful new model for studying the behavioral and molecular mechanisms of brain disorders.
Herbal medicine, a traditional way of treatment, is now modernized to provide a safe, eﬀective treatment to humans. For this, toxicological evaluation is critical in herbal medicine to discover side eﬀects and protect humans. This blog explains how zebraﬁsh can be used to assess the toxicity of these medicinal compounds.
The zebrafish (Danio rerio) has emerged as a powerful model for studying vertebrate development and disease. Its short generation time makes it amenable for genetic manipulation and analysis. Its small size and high fecundity help in large-scale genetic and chemical screening. The rapidly developing zebrafish embryos are transparent, which allows live imaging of various developmental processes in wild-type and mutant animals.
A research study on the exposure of Caffeine in zebrafish states that it can affect memory but may reduce stress. An overview of the research and the methods that have been carried out in the caffeine studies on zebrafish.
Zebrafish are an example of a model species in which results from probiotic experiments can be used as a reference for human treatment as they have similar intestinal microbiota and colonization patterns.
Regenerative medicine is rapidly gaining huge strides in recent times due to evolving technology and techniques in current use. Zebrafish is one of the very few model animals that can regenerate its organs. In this article, we describe the use of Zebrafish in regenerative medicine and its various methods.
During spinal cord injury, prolonged inflammation in the injury site Makes Re-generation of nerve cell connections difficult. So in order to understand in detail the responsible factor that causes inflammation we use zebrafish as our model organism which uses blood-derived macrophage for recovery from spinal cord injury.
Heart failure is a silent yet deadly disease that has steadily risen this past decade due to the increase in the aging population. An alarming trend of heart failure in the young population has also been observed. To study this disease and find treatments or drugs for it, it is necessary to create a pre-clinical model. We describe the methods of creating a zebrafish model in heart failure along with its testing parameters.
Rooibos can help fight skin, liver, colon, and oesophageal cancers, as well as diabetes and obesity. With the help of our zebrafish model, we prove that rooibos tea can be effective drug treatment for diabetic patients.
Zebrafish embryos are exposed to industrial wastewater in a range of dilutions, demonstrating that they are a very sensitive creature to the toxins found in industrial effluent.