Month December 2021

Zebrafish and Inflammatory Bowel Disease

Zebrafish Modeling
Scientists have used inflammatory bowel disease (IBD) animal models for drug-induced, genetic engineering studies for over 100 years. No other model like zebrafish precisely matches the pathophysiology of IBD of humans. The immune system of zebrafish is very similar to that of humans. Zebrafish have served similar orthologs of human IBD susceptibility genes NOD1 and NOD2 and have orthologs of mammalian Toll-like receptors (TLRs).